Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma
Dale, C Jane; Zhao, Anne; Jones, Stephen; Boyle, David B; Ramshaw, Ian; Kent, Stephen J
Description
Preventive and/or therapeutic vaccines against Human Immunodeficiency Virus (HIV-1) are urgently required. Induction of cellular immunity is favoured since these responses correlate with control of HIV-1. Recombinant fowlpoxvirus (FPV) vaccines encoding both HIV-1 gag/pol and interferon-gamma (FPV gag/pol-IFNγ) were hypothesised to enhance HIV-specific cellular immunity and were further evaluated in macaques previously infected with HIV-1. A novel assay to detect IFNγ secretion following HIV...[Show more]
Collections | ANU Research Publications |
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Date published: | 2000 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/90211 |
Source: | Journal of Medical Primatology |
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01_Dale_Induction_of_HIV-1-specific__2000.pdf | 246.55 kB | Adobe PDF | Request a copy |
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