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Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma

Dale, C Jane; Zhao, Anne; Jones, Stephen; Boyle, David B; Ramshaw, Ian; Kent, Stephen J


Preventive and/or therapeutic vaccines against Human Immunodeficiency Virus (HIV-1) are urgently required. Induction of cellular immunity is favoured since these responses correlate with control of HIV-1. Recombinant fowlpoxvirus (FPV) vaccines encoding both HIV-1 gag/pol and interferon-gamma (FPV gag/pol-IFNγ) were hypothesised to enhance HIV-specific cellular immunity and were further evaluated in macaques previously infected with HIV-1. A novel assay to detect IFNγ secretion following HIV...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Medical Primatology


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