Crouch, Michael F
The 70 kDa ribosomal S6 kinase (p70(S6K)) is activated by numerous mitogens, growth factors and hormones. Activation of p70(S6K) occurs through phosphorylation at a number of sites and the primary target of the activated kinase is the 40S ribosomal protein S6, a major component of the machinery involved in protein synthesis in mammalian cells. In addition to its involvement in regulating translation, p70(S6K) activation has been implicated in cell cycle control and neuronal cell...[Show more]
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