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Electron Microscopic Evidence for the Assembly of Soluble Pentameric Extracellular Domains of the Nicotinic Acetylcholine Receptor

Tierney, Mary (Louise); Unwin, Nigel

Description

Exploitation of soluble extracellular domains (ECDs) of the nicotinic acetylcholine receptor may provide a route to crystallographic studies aimed at exploring the structure and function of the intact receptor. The first step towards this goal is to manufacture and isolate soluble fragments that fold and assemble to form a functionally relevant complex. The baculovirus insect cell expression system was used to co-express soluble ECDs of all four muscle-type nicotinic acetylcholine receptor...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/90177
Source: Journal of Molecular Biology
DOI: 10.1006/jmbi.2000.4137

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