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Evaluation of Enzymatic Mutaton DetectionTM in Hereditary Nonpolyposis Colorectal Cancer

Otway, R; Tetlow, Natasha; Hornby, June; Kohonen-Corish, M K


In hereditary nonpolyposis colorectal cancer (HNPCC), the majority of reported mutations are dispersed throughout the 35 exons of the two principal susceptibility genes, MLH1 and MSH2, and because of this complexity, rapid mutation screening methods are required. The aim of this study was to evaluate the sensitivity of the Enzymatic Mutation Detection(TM) (EMD(TM)) assay in HNPCC using genomic DNA samples with known gene alterations in MLH1 and MSH2. The EMD assay relies upon the enzyme T4...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Human Mutation
DOI: 10.1002/1098-1004(200007)16:1<61::AID-HUMU11>3.0.CO;2-H


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