Replication restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation
Mukherjee, Sutapa; Haenel, Thomas; Himbeck, Robyn; Scott, Bernadette; Ramshaw, Ian; Lake, Richard A; Harnett, J; Phillips, Peter; Morey, Sue; Smith, David; Davidson, J Andrew; Musk, Arthur W; Robinson, Bruce
Background: As antitumoral immunity requires the generation of local immunity directed against tissue proteins, we attempted to recreate within tumors the same environment found within tissues affected by autoimmune diseases (i.e., prolonged cytokine expression). Vaccinia virus (VV) has not been widely used as a cytokine gene therapy vector because of presumed high immunogenicity that would likely make repeated injections impossible; therefore, we modified it by inserting the cytokine gene into...[Show more]
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|Source:||Cancer Gene Therapy|
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