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The effect of IL-5 eotaxin expression in the lung on eosinophil traffickling and degranulation and the induction of bronchial hyperreactivity

Mould, A; Ramsay, Alistair; Matthaei, Klaus; Young, I M; Rothenberg, Marc E; Foster, Paul S


The mechanisms regulating the selective migration and degranulation of eosinophils in the asthmatic lung and the subsequent development of airways hyperreactivity (AHR) have not been fully delineated. In this investigation, we have employed a novel transgene model to facilitate the dissection of the contributions of IL-5 and/or eotaxin to eosinophil function in the absence of complex tissue signals derived from the allergic lung. Gene transfer of IL-5 and/or eotaxin to the lungs of naive mice...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Immunology


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