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Phosphorylation of a new brain-specific Septin, G-septin, by cGMP-dependent protein kinase

Xue, Jing; Wang, Xing Li; Malladi, Chandra; Kinoshita, Mikoto; Milburn, Peter J; Lengyel, Imre; Rostas, John A P; Robinson, Phillip J


The septins are a family of GTPase enzymes, some of which are required for the cytokinesis stage of cell division and others of which are associated with exocytosis. We purified and cloned the cDNA for a 40-kDa protein from rat brain that is a substrate for type I cGMP-dependent protein kinase (PKG). The amino acid sequences of two tryptic peptides of P40 showed high homology to the septins. Molecular cloning revealed the 358-amino acid P40 to be a new member of the septin family. P40 was named...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.275.14.10047


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