Skip navigation
Skip navigation

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

Glynne, Richard; Akkaraju, Srinivas; Healy, James I; Rayner, J; Goodnow, Christopher; Mack, David H

Description

Therapy for transplant rejection, autoimmune disease and allergy must target mature lymphocytes that have escaped censoring during their development. FK506 and cyclosporin are immunosuppressants which block three antigen-receptor signalling pathways (NFAT, NFκB and JNK), through inhibition of calcineurin, and inhibit mature lymphocyte proliferation to antigen. Neither drug induces long-lived tolerance in vivo, however, necessitating chronic use with adverse side effects. Physiological...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89978
Source: Nature
DOI: 10.1038/35001102

Download

File Description SizeFormat Image
01_Glynne_How_self-tolerance_and_the_2000.pdf476.84 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator