How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
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Glynne, Richard; Akkaraju, Srinivas; Healy, James I; Rayner, J; Goodnow, Christopher; Mack, David H
Description
Therapy for transplant rejection, autoimmune disease and allergy must target mature lymphocytes that have escaped censoring during their development. FK506 and cyclosporin are immunosuppressants which block three antigen-receptor signalling pathways (NFAT, NFκB and JNK), through inhibition of calcineurin, and inhibit mature lymphocyte proliferation to antigen. Neither drug induces long-lived tolerance in vivo, however, necessitating chronic use with adverse side effects. Physiological...[Show more]
Collections | ANU Research Publications |
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Date published: | 2000 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/89978 |
Source: | Nature |
DOI: | 10.1038/35001102 |
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01_Glynne_How_self-tolerance_and_the_2000.pdf | 476.84 kB | Adobe PDF | Request a copy |
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