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How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

Glynne, Richard; Akkaraju, Srinivas; Healy, James I; Rayner, J; Goodnow, Christopher; Mack, David H


Therapy for transplant rejection, autoimmune disease and allergy must target mature lymphocytes that have escaped censoring during their development. FK506 and cyclosporin are immunosuppressants which block three antigen-receptor signalling pathways (NFAT, NFκB and JNK), through inhibition of calcineurin, and inhibit mature lymphocyte proliferation to antigen. Neither drug induces long-lived tolerance in vivo, however, necessitating chronic use with adverse side effects. Physiological...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Nature
DOI: 10.1038/35001102


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