ROLE OF NITRIC OXIDE IN ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION: L-ARGININE EFFECTS REVERSED BY N-NITRO-L-ARGININE
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Wen, Cheng; Li, Ming; Whitworth, Judith
Description
1. L-Arginine prevents adrenocorticotrophin (ACTH)-induced hypertension in the rat. To confirm that this effect is mediated through the nitric oxide (NO) system, we examined whether N-nitro-L-arginine (NOLA) could reverse the L-arginine-induced blockade of ACTH-induced hypertension. 2. Blood pressure and metabolic parameters were examined in sham-, ACTH., L-arginine + sham-, NOLA + sham-, ACTH + L-arginine- and ACTH + L-arginine + NOLA-treated Sprague-Dawley rats (n = 40). 3....[Show more]
dc.contributor.author | Wen, Cheng | |
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dc.contributor.author | Li, Ming | |
dc.contributor.author | Whitworth, Judith | |
dc.date.accessioned | 2015-12-13T23:17:54Z | |
dc.identifier.issn | 0305-1870 | |
dc.identifier.uri | http://hdl.handle.net/1885/89915 | |
dc.description.abstract | 1. L-Arginine prevents adrenocorticotrophin (ACTH)-induced hypertension in the rat. To confirm that this effect is mediated through the nitric oxide (NO) system, we examined whether N-nitro-L-arginine (NOLA) could reverse the L-arginine-induced blockade of ACTH-induced hypertension. 2. Blood pressure and metabolic parameters were examined in sham-, ACTH., L-arginine + sham-, NOLA + sham-, ACTH + L-arginine- and ACTH + L-arginine + NOLA-treated Sprague-Dawley rats (n = 40). 3. Adrenocorticotrophin treatment increased systolic blood pressure (SBP), water intake and urine output and decreased bodyweight. N-Nitro-L-arginine alone increased SBP without affecting metabolic variables. L-Arginine alone did not affect blood pressure. The SBP was lower in L-arginine + ACTH- than ACTH-treated rats (P < 0.001), but was higher following ACTH + L-arginine + NOLA than ACTH + L-arginine (P < 0.05). 4. N-Nitro-L-arginine reversed the blood pressure-lowering effect of L-arginine in ACTH-induced hypertension in the rat, supporting the notion that NO plays a role in the hypertension. | |
dc.publisher | Blackwell Science Asia | |
dc.source | Clinical and Experimental Pharmacology and Physiology | |
dc.subject | Keywords: arginine; corticotropin; n(g) nitroarginine; nitric oxide; animal experiment; animal model; article; body weight; controlled study; fluid intake; hypertension; male; nonhuman; rat; systolic blood pressure; urine volume; Adrenocorticotropic Hormone; Animal Adrenocorticotrophin; Blood pressure; L-arginine; N-nitro-L-arginine; Rat | |
dc.title | ROLE OF NITRIC OXIDE IN ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION: L-ARGININE EFFECTS REVERSED BY N-NITRO-L-ARGININE | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 27 | |
dc.date.issued | 2000 | |
local.identifier.absfor | 110302 - Clinical Chemistry (diagnostics) | |
local.identifier.ariespublication | MigratedxPub20154 | |
local.type.status | Published Version | |
local.contributor.affiliation | Wen, Cheng, University of Sydney | |
local.contributor.affiliation | Li, Ming, University of Sydney | |
local.contributor.affiliation | Whitworth, Judith, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 11 | |
local.bibliographicCitation.startpage | 887 | |
local.bibliographicCitation.lastpage | 890 | |
local.identifier.doi | 10.1046/j.1440-1681.2000.03354.x | |
dc.date.updated | 2015-12-12T08:54:48Z | |
local.identifier.scopusID | 2-s2.0-0033767676 | |
Collections | ANU Research Publications |
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