ROLE OF NITRIC OXIDE IN ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION: L-ARGININE EFFECTS REVERSED BY N-NITRO-L-ARGININE
Wen, Cheng; Li, Ming; Whitworth, Judith
Description
1. L-Arginine prevents adrenocorticotrophin (ACTH)-induced hypertension in the rat. To confirm that this effect is mediated through the nitric oxide (NO) system, we examined whether N-nitro-L-arginine (NOLA) could reverse the L-arginine-induced blockade of ACTH-induced hypertension. 2. Blood pressure and metabolic parameters were examined in sham-, ACTH., L-arginine + sham-, NOLA + sham-, ACTH + L-arginine- and ACTH + L-arginine + NOLA-treated Sprague-Dawley rats (n = 40). 3....[Show more]
Collections | ANU Research Publications |
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Date published: | 2000 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/89915 |
Source: | Clinical and Experimental Pharmacology and Physiology |
DOI: | 10.1046/j.1440-1681.2000.03354.x |
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01_Wen_ROLE_OF_NITRIC_OXIDE_IN_2000.pdf | 131.02 kB | Adobe PDF | Request a copy |
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