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ROLE OF NITRIC OXIDE IN ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION: L-ARGININE EFFECTS REVERSED BY N-NITRO-L-ARGININE

Wen, Cheng; Li, Ming; Whitworth, Judith

Description

1. L-Arginine prevents adrenocorticotrophin (ACTH)-induced hypertension in the rat. To confirm that this effect is mediated through the nitric oxide (NO) system, we examined whether N-nitro-L-arginine (NOLA) could reverse the L-arginine-induced blockade of ACTH-induced hypertension. 2. Blood pressure and metabolic parameters were examined in sham-, ACTH., L-arginine + sham-, NOLA + sham-, ACTH + L-arginine- and ACTH + L-arginine + NOLA-treated Sprague-Dawley rats (n = 40). 3....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89915
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2000.03354.x

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