Euplectin and Coneuplectin, New Naphthopyrones from the Lichen Flavoparmelia euplecta
-
Altmetric Citations
Ernst-Russell, M; Chai, Christina; Wardlaw, Judith; Elix, John
Description
Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone...[Show more]
dc.contributor.author | Ernst-Russell, M | |
---|---|---|
dc.contributor.author | Chai, Christina | |
dc.contributor.author | Wardlaw, Judith | |
dc.contributor.author | Elix, John | |
dc.date.accessioned | 2015-12-13T23:17:52Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | http://hdl.handle.net/1885/89906 | |
dc.description.abstract | Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin. | |
dc.publisher | American Chemical Society | |
dc.source | Journal of Natural Products | |
dc.subject | Keywords: coneuplectin; euplectin; indanone derivative; pyrone derivative; unclassified drug; animal cell; article; cytotoxicity; drug isolation; high performance liquid chromatography; lichen; mastocytoma; nonhuman; nuclear magnetic resonance spectroscopy; structu | |
dc.title | Euplectin and Coneuplectin, New Naphthopyrones from the Lichen Flavoparmelia euplecta | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 63 | |
dc.date.issued | 2000 | |
local.identifier.absfor | 030499 - Medicinal and Biomolecular Chemistry not elsewhere classified | |
local.identifier.ariespublication | MigratedxPub20141 | |
local.type.status | Published Version | |
local.contributor.affiliation | Ernst-Russell, M, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Chai, Christina, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Wardlaw, Judith, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Elix, John, College of Physical and Mathematical Sciences, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 129 | |
local.bibliographicCitation.lastpage | 131 | |
local.identifier.doi | 10.1021/np9903245 | |
dc.date.updated | 2015-12-12T08:54:43Z | |
local.identifier.scopusID | 2-s2.0-0033952894 | |
Collections | ANU Research Publications |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Ernst-Russell_Euplectin_and_Coneuplectin,_2000.pdf | 39.97 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator