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Euplectin and Coneuplectin, New Naphthopyrones from the Lichen Flavoparmelia euplecta

Ernst-Russell, M; Chai, Christina; Wardlaw, Judith; Elix, John

Description

Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone...[Show more]

dc.contributor.authorErnst-Russell, M
dc.contributor.authorChai, Christina
dc.contributor.authorWardlaw, Judith
dc.contributor.authorElix, John
dc.date.accessioned2015-12-13T23:17:52Z
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/1885/89906
dc.description.abstractTwo new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.
dc.publisherAmerican Chemical Society
dc.sourceJournal of Natural Products
dc.subjectKeywords: coneuplectin; euplectin; indanone derivative; pyrone derivative; unclassified drug; animal cell; article; cytotoxicity; drug isolation; high performance liquid chromatography; lichen; mastocytoma; nonhuman; nuclear magnetic resonance spectroscopy; structu
dc.titleEuplectin and Coneuplectin, New Naphthopyrones from the Lichen Flavoparmelia euplecta
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume63
dc.date.issued2000
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub20141
local.type.statusPublished Version
local.contributor.affiliationErnst-Russell, M, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChai, Christina, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWardlaw, Judith, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationElix, John, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage129
local.bibliographicCitation.lastpage131
local.identifier.doi10.1021/np9903245
dc.date.updated2015-12-12T08:54:43Z
local.identifier.scopusID2-s2.0-0033952894
CollectionsANU Research Publications

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