Entry of B cell receptor into signaling domains is inhibited in tolerant B cells
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Weintraub, Bennet C.; Jun, Jesse; Bishop, Adrian; Shokat, Kevan; Thomas, M; Goodnow, Christopher
Description
Signal transduction through the B cell antigen receptor (BCR) is altered in B cells that express a receptor that recognizes self-antigen. To understand the molecular basis for the change in signaling in autoreactive B cells, a transgenic model was used to isolate a homogeneous population of tolerant B lymphocytes. These cells were compared with a similar population of naive B lymphocytes. We show that the BCR from naive B cells enters a detergent-insoluble domain of the cell within 6 s after...[Show more]
Collections | ANU Research Publications |
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Date published: | 2000 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/89904 |
Source: | Journal of Experimental Medicine |
DOI: | 10.1084/jem.191.8.1443 |
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01_Weintraub_Entry_of_B_cell_receptor_into_2000.pdf | 182.38 kB | Adobe PDF | Request a copy |
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