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Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate

Tzeng, Huey-Fen; Blackburn, Anneke; Board, Philip; Anders, Michael

Description

Glutathione transferase zeta catalyzes the glutathione-dependent oxidation or conjugation of a range of α-haloacids. Repeated administration of dichloroacetate to human subjects increases its plasma elimination half- life, and the activity of glutathione

dc.contributor.authorTzeng, Huey-Fen
dc.contributor.authorBlackburn, Anneke
dc.contributor.authorBoard, Philip
dc.contributor.authorAnders, Michael
dc.date.accessioned2015-12-13T23:17:51Z
dc.identifier.issn0893-228X
dc.identifier.urihttp://hdl.handle.net/1885/89896
dc.description.abstractGlutathione transferase zeta catalyzes the glutathione-dependent oxidation or conjugation of a range of α-haloacids. Repeated administration of dichloroacetate to human subjects increases its plasma elimination half- life, and the activity of glutathione
dc.publisherAmerican Chemical Society
dc.sourceChemical Research in Toxicology
dc.subjectKeywords: acetic acid derivative; dichloroacetic acid; glutathione transferase; animal tissue; article; biotransformation; catalysis; enzyme inactivation; enzyme kinetics; enzyme polymorphism; human; human tissue; minimum inhibitory concentration; mouse; nonhuman;
dc.titlePolymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume13
dc.date.issued2000
local.identifier.absfor060107 - Enzymes
local.identifier.ariespublicationMigratedxPub20130
local.type.statusPublished Version
local.contributor.affiliationTzeng, Huey-Fen, National Chi Nan University
local.contributor.affiliationBlackburn, Anneke, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBoard, Philip, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAnders, Michael, University of Rochester
local.description.embargo2037-12-31
local.bibliographicCitation.startpage231
local.bibliographicCitation.lastpage236
local.identifier.doi10.1021/tx990175q
dc.date.updated2015-12-12T08:54:38Z
local.identifier.scopusID2-s2.0-0034053786
CollectionsANU Research Publications

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