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Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate

Tzeng, Huey-Fen; Blackburn, Anneke; Board, Philip; Anders, Michael

Description

Glutathione transferase zeta catalyzes the glutathione-dependent oxidation or conjugation of a range of α-haloacids. Repeated administration of dichloroacetate to human subjects increases its plasma elimination half- life, and the activity of glutathione

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89896
Source: Chemical Research in Toxicology
DOI: 10.1021/tx990175q

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