Webb, Dianne; Mckenzie, Andrew N; Koskinen, Aulikki; Yang, Ming; Mattes, Joerg; Foster, Paul S
In this investigation, we have examined the integrated relationship between IL-13, IL-4, and IL-5 for the development of airways hyperreactivity (AHR) in a model of asthma in BALB/c mice. Sensitization and aeroallergen challenge of both wild-type (WT) and IL-13 gene-targeted (IL-13(-/-)) mice induced allergic disease that was characterized by pulmonary eosinophilia and AHR to β-methacholine. Although these responses in IL-13(-/-) mice were heightened compared with WT, they could be reduced to...[Show more]
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