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Interleukin-5 deficient mice exhibit impaired host defence against challenge trichinell spiralis infections

Vallance, B; Matthaei, Klaus; Sanovic, S; Young, I M; Collins, Stephen Frederick

Description

Enteric nematode infections are characterized by both peripheral and tissue eosinophilia. The cytokine interleukin (IL)-5 is considered a critical factor in the proliferation and recruitment of eosinophils, however, studies suggest it plays little role in host defence, at least during primary Trichinella spiralis infections. Less is known concerning its role in host defence or in the inflammatory response that develops against challenge infections with the same parasite. We examined these...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89881
Source: Parasite Immunology
DOI: 10.1046/j.1365-3024.2000.00328.x

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