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VASOPRESSIN V1A RECEPTOR ANTAGONISM DOES NOT REVERSE ADRENOCORTICOTROPHIN-INDUCED HYPERTENSION IN THE RAT

Fraser, Tafline; Turner, Steven; Wen, Cheng; Li, Ming; Burrell, L; Whitworth, Judith

Description

1. The role of arginine vasopressin (AVP) was examined in adrenocorticotrophin (ACTH)-induced hypertension in Sprague-Dawley rats using the non-peptide AVP V(1a) receptor antagonist OPC 21268. 2. In an acute study, six rats were pretreated with ACTH for 11 days and direct arterial blood pressure (4 h), plasma osmolality and electrolyte concentrations were measured after OPC 21268 gavage. In a chronic study, 40 rats were randomly divided into four groups: (i) sham injection + sham gavage; (ii)...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89821
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2000.03350.x

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