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Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma

Foster, Paul S; Yang, Ming; Matthaei, Klaus; Young, I M; Temelkovski, J; Kumar, Rakesh K


To study pathogenetic mechanisms in chronic asthma, we employed a novel experimental model that replicates characteristic features of the human disease. Chronic inflammation and epithelial changes, specifically localized to the airways, were induced by repeated exposure of systemically sensitized BALB/c mice to low mass concentrations of aerosolized ovalbumin for 6 weeks. The contribution of Th2 cytokine-driven inflammation to the development of airway lesions and hyperreactivity was assessed...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Laboratory Investigation


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