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Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice

Stevceva, L; Pavli, Paul; Husband, Alan J; Matthaei, Klaus; Young, I M; Doe, W


Tissue eosinophilia is a feature of idiopathic inflammatory bowel disease and other forms of colonic inflammation but it is not clear whether the role of eosinophils in the disease process is to contribute to tissue damage, Interleukin 5 (IL-5) stimulates production and activation of eosinophils in vitro and enhances immunoglobulin A (IgA) production. As very little is known about the function of IL-5 in the colon, the aim of this study was to assess its role in colonic inflammation. IL-5...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Genes and Immunity


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