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Recombinant adenovirus vectors expressing interleukin-5 and -6 specifically enhance mucosal immunoglobulin A responses in the lung

Braciak, Todd; Gallichan, W; Graham, F L; Richards, C; Ramsay, Alistair; Rosenthal, K; Gauldie, J


In this study, we have examined the in vivo effects of interleukin-5 (IL-5) and IL-6 over-expression on systemic and mucosal immune responses using recombinant human type 5 adenoviruses capable of expressing these cytokines upon infection. A recombinant adenovirus containing the murine IL-5 gene within the E3 region was constructed and found to express high levels of IL-5 protein both in vitro and in vivo. Intranasal inoculation of mice with this vector or a vector expressing murine IL-6...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Immunology
DOI: 10.1046/j.1365-2567.2000.00116.x


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