Prasad, S; Goodnow, Christopher
Genes outside the MHC create a general susceptibility to autoimmunity in non-obese diabetic (NOD) mice. Here we describe marked differences in dendritic cell generation in vivo, caused by non-MHC NOD genes. Analyses of splenic dendritic cells from the autoimmunity-prone NOD.H-2k mice revealed a relative over-representation of the CD8α- subsets, in contrast to the level of these subsets observed in the autoimmunity-resistant B10.H-2k congenic strain or other H-2k strains. The imbalance towards...[Show more]
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