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Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing

Halenius, Anne; Momburg, Frank; Reinhard, Henrike; Bauer, Dagmar; Lobigs, Mario; Hengel, Hartmut

Description

The endoplasmic reticulum-resident human cytomegalovirus glycoprotein US6 (gpUS6) inhibits peptide translocation by the transporter associated with antigen processing (TAP) to prevent loading of major histocompatibility complex class I molecules and antigen presentation to CD8+ T cells. TAP is formed by two subunits, TAP1 and TAP2, each containing one multispanning transmembrane domain (TMD) and a cytosolic nucleotide binding domain. Here we reported that the blockade of TAP by gpUS6 is...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/89732
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M510223200

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