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Aire regulates negative selection of organ-specific T cells

Liston, Adrian; Lesage, Sylvie; Wilson, Judith; Peltonen, L; Goodnow, Christopher


Autoimmune polyendocrinopathy syndrome type I is a recessive Mendelian disorder resulting from mutations in a novel gene, AIRE, and is characterized by a spectrum of organ-specific autoimmune diseases. It is not known what tolerance mechanisms are defective as a result of AIRE mutation. By tracing the fate of autoreactive CD4+ T cells with high affinity for a pancreatic antigen in transgenic mice with an Aire mutation, we show here that Aire deficiency causes almost complete failure to delete...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Nature Immunology
DOI: 10.1038/ni906


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