Skip navigation
Skip navigation

Protective Vaccine Efficacy when Vaccine Response is Random

Becker, Niels; Utev, Sergey


Vaccine induced protection against infection is often random because of primary vaccine failures and variation in the immune systems of hosts. We introduce a concept of protective vaccine efficacy in terms of mean relative susceptibility of vaccinated individuals and derive both a lower and an upper bound for it. These bounds apply for all distributions of the vaccine response and can be estimated from data on the size of a major epidemic. Standard errors are given for estimates of the bounds....[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Biometrical Journal
DOI: 10.1002/1521-4036(200201)44:1<29::AID-BIMJ29>3.0.CO;2-8


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator