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Protective Vaccine Efficacy when Vaccine Response is Random

Becker, Niels; Utev, Sergey

Description

Vaccine induced protection against infection is often random because of primary vaccine failures and variation in the immune systems of hosts. We introduce a concept of protective vaccine efficacy in terms of mean relative susceptibility of vaccinated individuals and derive both a lower and an upper bound for it. These bounds apply for all distributions of the vaccine response and can be estimated from data on the size of a major epidemic. Standard errors are given for estimates of the bounds....[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/89698
Source: Biometrical Journal
DOI: 10.1002/1521-4036(200201)44:1<29::AID-BIMJ29>3.0.CO;2-8

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