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Animal models of NASH: getting both pathology and metabolic context right

Larter, Claire Z.; Yeh, Matthew M.


Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease. The main risk factors for NAFLD/NASH are the metabolic abnormalities commonly observed in metabolic syndrome: insulin resistance, visceral obesity, dyslipidemia and altered adipokine profile. At present, the causes of progression from NAFLD to NASH remain poorly defined, and research in...[Show more]

CollectionsANU Research Publications
Date published: 2008-08-21
Type: Journal article
Source: Journal of Gastroenterology and Hepatology 23.11 (2008): 1635-1648
DOI: 10.1111/j.1440-1746.2008.05543.x


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