Keniry, Max; Carver, John
Traditionally, the major obstacle to using NMR spectroscopy to gain meaningful structural information about proteins of mass greater than around 25kDa has been the poor quality of spectra. In this chapter, we discuss inherent ways and recent advances in NMR methodology that can be used to circumvent or overcome the problem of poorly resolved spectra. For example, some large proteins have functionally significant regions of inherent flexibility that are observable by NMR spectroscopy. In the...[Show more]
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