Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptors
-
Altmetric Citations
Pogue, Sarah; Goodnow, Christopher
Description
Conserved differences between the transmembrane and cytoplasmic domains of membrane immunoglobulin (Ig)M and IgG may alter the function of antigen receptors on naive versus memory B cells. Here, we compare the ability of these domains to signal B cell allelic exclusion and maturation in transgenic mice. A lysozyme-binding antibody was expressed in parallel sets of mice as IgM, IgG1, or a chimeric receptor with IgM extracellular domains and transmembrane/cytoplasmic domains of IgG1. Like IgM,...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2000 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/89613 |
Source: | Journal of Experimental Medicine |
DOI: | 10.1084/jem.191.6.1031 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Pogue_Gene_dose-dependent_maturation_2000.pdf | 306.48 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 19 May 2020/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator