Interaction of substituted cobalt(III) cage complexes with DNA
Polycyclic aromatic moieties covalently bound to the inert cationic cobalt(III)-sar cage complex (sar = sarcophagine = 3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane) intercalate with negatively supercoiled plasmid DNA, as shown by both spectrophotometric and gel electrophoresis studies. Although anthracene itself is not a good intercalating agent, the association constant of the complex between anthracene tied to the cobalt(III)-sar cage and DNA is ≈2 × 106 dm3 mol-1 and the average binding-site...[Show more]
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