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Human and mouse homologues of the drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins

Campbell, Hugh; Kamei, M; Claudianos, Charles; Woollatt, E; Sutherland, Grant; Suzuki, Yutaka; Hida, Munetomo; Sugano, Sumio; Young, I M

Description

We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene...[Show more]

dc.contributor.authorCampbell, Hugh
dc.contributor.authorKamei, M
dc.contributor.authorClaudianos, Charles
dc.contributor.authorWoollatt, E
dc.contributor.authorSutherland, Grant
dc.contributor.authorSuzuki, Yutaka
dc.contributor.authorHida, Munetomo
dc.contributor.authorSugano, Sumio
dc.contributor.authorYoung, I M
dc.date.accessioned2015-12-13T23:16:39Z
dc.identifier.issn0888-7543
dc.identifier.urihttp://hdl.handle.net/1885/89516
dc.description.abstractWe have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene was determined. The mouse protein is 91% identical to the human protein. Hydrophobicity analysis of the tty-related proteins indicates that they represent a new family of membrane proteins with five potential membrane-spanning regions. The yeast FTR1 and FTH1 iron transporter proteins and the mammalian neurotensin receptors 1 and 2 have a similar hydrophobicity profile, although there is no detectable sequence homology to the tty-related proteins. This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors. TTYH1 was mapped to chromosome 19q13.4 by FISH and by radiation hybrid mapping using the Stanford G3 panel. (C) 2000 Academic Press.
dc.publisherAcademic Press
dc.sourceGenomics
dc.subjectKeywords: membrane protein; neurotensin receptor; amino acid sequence; article; Caenorhabditis elegans; cation transport; Drosophila melanogaster; human; iron transport; Macaca; molecular cloning; nonhuman; nucleotide sequence; priority journal; sequence homology;
dc.titleHuman and mouse homologues of the drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume68
dc.date.issued2000
local.identifier.absfor110106 - Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
local.identifier.ariespublicationMigratedxPub19573
local.type.statusPublished Version
local.contributor.affiliationCampbell, Hugh, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKamei, M, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationClaudianos, Charles, CSIRO
local.contributor.affiliationWoollatt, E, Women's and Children's Hospital
local.contributor.affiliationSutherland, Grant, Women's and Children's Hospital
local.contributor.affiliationSuzuki, Yutaka, University of Tokyo
local.contributor.affiliationHida, Munetomo, University of Tokyo
local.contributor.affiliationSugano, Sumio, University of Tokyo
local.contributor.affiliationYoung, I M, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage89
local.bibliographicCitation.lastpage92
local.identifier.doi10.1006/geno.2000.6259
dc.date.updated2015-12-12T08:49:05Z
local.identifier.scopusID2-s2.0-0034662787
CollectionsANU Research Publications

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