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Release probability modulates short-term plasticity at a rat giant terminal

Oleskevich, Sharon; Clements, John D; Walmsley, Bruce


1. Modulation of release probability is a major factor underlying short-term synaptic plasticity in the central nervous system. We have investigated the relationship between release probability (P(r)) and paired-pulse modulation at a large auditory calyceal synapse containing many transmitter release sites. Whole-cell patch electrode recordings were made of excitatory postsynaptic currents (EPSCs), evoked by stimulation of auditory nerve fibres giving rise to the endbulbs of Held. 2....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Physiology


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