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Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat

Turner, Steven; Mangos, George; Whitworth, Judith


1. The nitric oxide (NO) system has been implicated in the pathogenesis of various forms of experimental hypertension. We studied nitric oxide synthase (NOS) activity as a possible indicator of NO production in adrenocorticotrophin (ACTH)-induced hypertension in the rat. 2. Haemodynamic, metabolic and biochemical parameters were examined in sham (saline)- and ACTH (100 μg/kg per day)-treated male Sprague-Dawley rats (n = 20). 3. Adrenocorticotrophin treatment increased systolic blood pressure,...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2001.03539.x


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