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The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states

Fan, Jun; Gordon, Faye; Luger, Karolin; Hansen, Jeffrey; Tremethick, David


Explaining the determinants involved in regulating the equilibrium between different chromatin structural states is fundamental to understanding differential gene expression. Histone variant H2A.Z is essential to chromatin architecture in higher eukaryotes but its role has not yet been explained. We show here that H2A.Z facilitates the intramolecular folding of nucleosomal arrays while simultaneously inhibiting the formation of highly condensed structures that result from intermolecular...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Nature Structural Biology
DOI: 10.1038/nsb767


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