The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat
Objective: Corticotrophin (ACTH)-induced hypertension in the rat is prevented by L- but not D-arginine. We examined the effects of exogenous corticosterone in the male Sprague Dawley (SD) rat to determine whether ACTH-induced hypertension is mediated by corticosterone. Methods: Exogenous corticosterone (10, 20 or 40 mg/kg per day) or sham (polyethylene glycol (PEG) 1 ml/kg per day) was injected subcutaneously in divided doses (s/c b.d.) over 15 treatment days to 40 SD rats (n = 10 each group)....[Show more]
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|Source:||Journal of Hypertension|
|01_Mangos_The_role_of_corticosterone_in_2000.pdf||195.24 kB||Adobe PDF||Request a copy|
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