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Regulation of lipopolysaccharide-induced B-cell activation: Evidence that surface immunoglobulin mediates two independently regulated signals

Mamchak, A; Hodgkin, Phillip D


An antigen-specific B cell response can be induced by low concentrations of haptenated lipopolysaccharide (LPS), whereas high concentrations are inhibitory. Two explanations have been proposed for the latter phenomenon. In the first, specific surface Ig focuses LPS to the B cell membrane, where high local concentrations of the mitogen become paralytic for B cell responses. In the alternative, transmission of an antigen signal at higher concentrations of hapten LPS actively inhibits the...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2000.00896.x


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