Absence of lipopolysaccharide high-dose paralysis in B-cell responses: Implications for the one-signal theory
Over 20 years ago, Coutinho and Moller reported that high concentrations of LPS were paralytic for the development of antibody secreting cells (ASC). This data was used to explain bell-shaped dose-response curves observed for antihapten antibody formation in response to haptenated LPS. In turn, this bell curve was used to formulate the one-signal model of B cell activation, which argued that antigen signalling was generally unimportant to B cell responses. The present paper re-examines LPS...[Show more]
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|Source:||Immunology and Cell Biology|
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