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Macrophage-induced muscle pathology results in morbidity and mortality for Ross River virus-infected mice

Lidbury, Brett; Simeonovic, Charmaine; Maxwell, Georgina; Marshall, I; Hapel, Andrew


Ross River virus (RRV) is an Australian alphavirus that is often responsible for chronic epidemic polyarthritis and myalgia in humans. Past studies have shown severe disruption of striated muscle fibers to be prominent in RRV pathology in mice; in the present study, macrophages were directly implicated as the primary mediators of muscle damage. General immunosuppressive therapies had only minor effects on mortality and morbidity in RRV-infected mice, with no inhibition of muscle damage....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Infectious Diseases
DOI: 10.1086/315164


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