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Nuclear and nucleolar localization pf parathyroid hormone-related protein

Lam, Mark H C; Thomas, Rachel; Martin, T J; Gillespie, M T; Jans, David A

Description

Parathyroid hormone-related protein (PTHrP) was first discovered as the factor causing hyper-calcaemia produced by solid tumours frequently associated with the head and neck, breast, lung and kidney. The homolggy of its amino-terminus to parathyroid hormone (PTH; eight of the first 13 residues are identical), enables it to share the same receptor and perform similar biological functions to PTH. The sequences of PTHrP C-terminal to its PTH-like region confer functions such as transplacental...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89165
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2000.00919.x

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