Lam, Mark H C; Thomas, Rachel; Martin, T J; Gillespie, M T; Jans, David A
Parathyroid hormone-related protein (PTHrP) was first discovered as the factor causing hyper-calcaemia produced by solid tumours frequently associated with the head and neck, breast, lung and kidney. The homolggy of its amino-terminus to parathyroid hormone (PTH; eight of the first 13 residues are identical), enables it to share the same receptor and perform similar biological functions to PTH. The sequences of PTHrP C-terminal to its PTH-like region confer functions such as transplacental...[Show more]
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