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Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis.

Chen, Xin Jie; Bauer, Bettina; Kuchler, Karl; Clark-Walker, George


The nuclear gene encoding the Sit4 protein phosphatase was identified in the budding yeast Kluyveromyces lactis. K. lactis cells carrying a disrupted sit4 allele are resistant to oligomycin, antimycin, ketoconazole, and econazole but hypersensitive to paromomycin, sorbic acid, and 4- nitroquinoline-N-oxide (4-NQO). Overexpression of SIT4 leads to an elevation in resistance to paromomycin and to lesser extent tolerance to sorbic acid, but it has no detectable effect on resistance to 4-NQO. These...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.275.20.14865


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