Skip navigation
Skip navigation

Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis.

Chen, Xin Jie; Bauer, Bettina; Kuchler, Karl; Clark-Walker, George

Description

The nuclear gene encoding the Sit4 protein phosphatase was identified in the budding yeast Kluyveromyces lactis. K. lactis cells carrying a disrupted sit4 allele are resistant to oligomycin, antimycin, ketoconazole, and econazole but hypersensitive to paromomycin, sorbic acid, and 4- nitroquinoline-N-oxide (4-NQO). Overexpression of SIT4 leads to an elevation in resistance to paromomycin and to lesser extent tolerance to sorbic acid, but it has no detectable effect on resistance to 4-NQO. These...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89130
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.275.20.14865

Download

File Description SizeFormat Image
01_Chen_Positive_and_negative_control_2000.pdf909.24 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator