Supramolecular Structure and Nuclear targeting efficiency Determine the Enhancement of Transfection by Modified Polylysines
Chan, Chee Kai; Senden, Timothy; Jans, David A
Polylysine (ply) has been used as a DNA carrier in nonviral gene delivery systems because it forms complexes with plasmid DNA via charge interaction, and condenses it into a compact structure. We have recently shown that cross-linking nuclear localization sequences (NLSs) to ply can enhance transfection by conferring specific recognition by the cellular nuclear import 'receptor', the NLS-binding importin α/β heterodimer. The present study examines and correlates for the first time the effect of...[Show more]
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