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Nuclear targeting signal recognistion: a key control point in nuclear transport?

Jans, David A; Xiao, Chong-Yun; Lam, Mark H C


Recent progress indicates that there are multiple pathways of nucleocytoplasmic transport which involve specific targeting sequences, such as nuclear localization sequences (NLSs), and cytosolic receptor molecules of the importin/karyopherin superfamily which recognise and dock the NLS-containing proteins at the nuclear pore. This first step of nuclear import/export is of central importance, with the affinity of the importin-targeting sequence interaction a critical parameter in determining...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Bioessays
DOI: 10.1002/(SICI)1521-1878(200006)22:6<532::AID-BIES6>3.0.CO;2-O


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