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How important is DNA replication for mutagenesis?

Huttley, Gavin Austin; Jakobsen, I; Easteal, Simon


Rates of mutation and substitution in mammals are generally greater in the germ lines of males. This is usually explained as resulting from the larger number of germ cell divisions during spermatogenesis compared with oogenesis, with the assumption made that mutations occur primarily during DNA replication. However, the rate of cell division is not the only difference between male and female germ lines, and mechanisms are known that can give rise to mutations independently of DNA replication....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Molecular Biology and Evolution


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