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Role of gap junctions in acetylcholine-induced vasodilation of proximal and distal arteries of the rat mesentery

Hill, Caryl; Hickey, Haruyo; Sandow, Shaun L

Description

We have previously shown that myoendothelial gap junctions are more prevalent in distal than in proximal arteries of the rat mesentery. In the present study we have investigated the role of gap junctions in the mechanism of action of endothelium-derived hyperpolarizing factor (EDHF) in these same vessels following relaxation with acetylcholine. Arteries were pre- constricted with phenylephrine and concentration response curves to acetylcholine were constructed in the presence of...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89032
Source: Autonomic Neuroscience: Basic and Clinical
DOI: 10.1016/S0165-1838(00)00113-2

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