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Hypertolerance to morphine in G(zalpha)-deficient mice

Hendry, Ian; Kelleher, Kim; Bartlett, Selena; Leck, Kwong-Joo; Reynolds, Anna; Heydon, Katharina; Mellick, A; Megirian, David; Matthaei, Klaus

Description

Our laboratory has generated a mouse deficient in the alpha (α) subunit of the G protein, G(z), (G(zα)) gene and we have examined the involvement of G(zα) in spinal and supraspinal analgesia and tolerance mechanisms. Spinal analgesia was tested by the

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89026
Source: Brain Research
DOI: 10.1016/S0006-8993(00)02387-8

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