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High-Mobility-Group Protein I Can Modulate Binding of Transcription Factors to the U5 Region of the Human Immunodificiency Virus Type 1 Proviral Promoter

Henderson, A Scott; Bunce, Michael; Siddon, Nicole; Reeves, Raymond; Tremethick, David


HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner anti with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces. To investigate the hypothesis that HMG I/Y may have a role in human immunodeficiency virus type 1 (HIV-1) expression, we have analyzed whether HMG I/Y interacts with the 5' long terminal repeat anti whether this interaction can modulate transcription factor binding....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.74.22.10523-10534.2000


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