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b-Scission of C-3 (b-Carbon) Alkoxyl Radicals on Peptides and Proteins: A Novel Pathway Which Results in the Formation of a-Carbon Radicals and the Loss of Amino Acid Side Chains

Headlam, Henrietta; Mortimer, Adam; Easton, Christopher; Davies, Michael J

Description

Exposure of proteins to radicals in the presence of O2 brings about multiple changes in the target molecules. These alterations include oxidation of side chains, fragmentation, cross-linking, changes in hydrophobicity and conformation, altered susceptibility to proteolytic enzymes, and formation of new reactive groups, including hydroperoxides. These processes can result in the loss of structural or enzymatic activity. Backbone fragmentation is known to occur via a number of mechanisms, most of...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89017
Source: Chemical Research in Toxicology
DOI: 10.1021/tx0001171

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