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Identification of active site residues of the pro-metastatic endoglycosidase heparanase

Hulett, Mark; Hornby, June; Ohms, Stephen J; Zuegg, J.; Freeman, Craig; Gready, Jill; Parish, Christopher


Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS) and has been implicated in many important physiological and pathological processes, including tumor cell metastasis, angiogenesis, and leukocyte migration. We report herein the ident

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Biochemistry
DOI: 10.1021/bi002080p


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