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A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrontestinal allergy

Hogan, Simon P; Mishra, Anil; Brandt, Eric; Foster, Paul S; Rothenberg, Marc E


Despite marked advances in the understanding of allergic responses, the mechanisms regulating gastrointestinal allergy are not very well understood. We have developed a model of antigen-induced eosinophil-associated gastrointestinal allergy and characterized the role of eotaxin and IL-5. Challenge of allergen-sensitized mice with oral allergen, in the form of enteric-coated beads, resulted in marked allergen-specific IgG1 and IgE, Th2-type (IL-4 and IL-5) cytokine production, and eosinophil...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.97.12.6681


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