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Oxygen-sensing persistent sodium channels in rat hippocampus

Hammarstrom, Anna; Gage, Peter


1. Persistent sodium channel activity was recorded before and during hypoxia from cell-attached and inside-out patches obtained from cultured hippocampal neurons at a pipette potential (V(p)) of +30 mV. Average mean current (I') of these channels was very low under normoxic conditions and was similar in cell-attached and excised inside-out patches (-0.018 ± 0.010 and -0.025 ± 0.008 pA, respectively, n = 24). 2. Hypoxia increased the activity of persistent sodium channels in 10 cell-attached...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Physiology


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