Insulin induces epidermal growth factor EGF receptor clustering and potentiates EGF-stimulated DNA synthesis in Swiss 3T3 cells: A mechanism for costimulation in mitogenic synergy
In many cellular systems, activation with more than one ligand can produce a cellular response that is greater than the sum of the individual responses to the ligands. This synergy is sometimes referred to as coactivation. In Swiss 3T3 fibroblasts, activation of the epidermal growth factor (EGF) receptor produces a weak induction of DNA synthesis. Insulin has no stimulatory effect on this response. However, in combination, EGF and insulin synergize to cause a large induction of S phase. The...[Show more]
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