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Automated Protein Design and Sequence 0ptimisation: Scoring Functions and the Search Problem

Cootes, Adrian; Curmi, Paul; Torda, Andrew


Advances in molecular biology may mean that almost any protein sequence can be synthesised, but perhaps this has served to highlight the inadequacy of theoretical work. For a given protein fold, it is probably not possible to reliably predict an "ideal" sequence. We identify and survey several aspects of the problem. Firstly, it is not clear what is the best way to score a sequence-structure pair. Secondly, there is no consensus as to what the score function should represent (free energy or...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Current Protein and Peptide Science


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